Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium.

ERGÜL M., TURGUT N. H., SARAÇ B., ALTUN A., YILDIRIM Ş., BAĞÇİVAN İ.

European journal of obstetrics, gynecology, and reproductive biology, cilt.202, ss.45-50, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 202
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejogrb.2016.04.031
  • Dergi Adı: European journal of obstetrics, gynecology, and reproductive biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.45-50
  • Anahtar Kelimeler: Rho-kinase inhibitor, AS1892802, Fasudil hydrochloride, Myometrium, Tocolysis, CANCER-THERAPY, PRETERM BIRTH, GTPASES, CALCIUM, CELLS, LABOR
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The activation of Rho A/ROCK system is thought to be effective on the termination time of the pregnancy process. The aim of this study, was to investigate in vitro effects of the ROCK enzyme inhibitors, clinically available fasudil hydrochloride, and a new promising inhibitor AS1892802, on the contractions of isolated pregnant rat myometrium.