Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium.


ERGÜL M. , TURGUT N. H. , SARAÇ B. , ALTUN A. , YILDIRIM Ş. , BAĞÇİVAN İ.

European journal of obstetrics, gynecology, and reproductive biology, cilt.202, ss.45-50, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 202
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejogrb.2016.04.031
  • Dergi Adı: European journal of obstetrics, gynecology, and reproductive biology
  • Sayfa Sayıları: ss.45-50

Özet

Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The activation of Rho A/ROCK system is thought to be effective on the termination time of the pregnancy process. The aim of this study, was to investigate in vitro effects of the ROCK enzyme inhibitors, clinically available fasudil hydrochloride, and a new promising inhibitor AS1892802, on the contractions of isolated pregnant rat myometrium.