Three-Step Synthesis of 2,4-Diaryl-5,6,7,8-tetrahydroquinoline Derivatives


Gezegen H. , Dingil A., Ceylan M.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.47, pp.1017-1024, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47
  • Publication Date: 2010
  • Doi Number: 10.1002/jhet.409
  • Title of Journal : JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Page Numbers: pp.1017-1024

Abstract

Addition of cylohexanone to chalcones, obtained from the appropriate acetophenone and benzaldehyde derivatives, under solvent-free conditions gave 1,5-diketones in good yields. Treatment of 1,5-diketones with ammonium acetate in acetic acid afforded directly 2,4-diaryl-5,6,7,8-tetrahydroquinoline derivatives (7a-u) in high yields. The structures of 7a-u were elucidated by (1)H NMR, (13)C NMR, IR, and elemental analysis.