Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, cilt.99, sa.5, ss.461-467, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 99 Sayı: 5
- Basım Tarihi: 2021
- Doi Numarası: 10.1139/cjpp-2020-0218
- Dergi Adı: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, MEDLINE, SportDiscus, Veterinary Science Database
- Sayfa Sayıları: ss.461-467
- Anahtar Kelimeler: opioid, ghrelin receptors, hexarelin, GHRP-6, morphine tolerance, SUPRASPINAL LEVEL, NEUROPATHIC PAIN, ANALGESIA, HYPERALGESIA, INVOLVEMENT, EXPRESSION, WITHDRAWAL, MECHANISM, PATHWAY
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Ghrelin, a peptide hormone released from the gastric endocrine glands, shows analgesic activity apart from its various physiological effects. Nevertheless, the effects of ghrelin receptor (GHS-R) agonists on morphine analgesia and tolerance have not yet been elucidated. The purpose of this study was to evaluate the effects of the ghrelin receptor agonist hexarelin and antagonist [D-Lys3]-GHRP-6 on morphine antinociception and tolerance in rats. A total of 104 Wistar albino male adult rats (weighing approximately 220-240 g) were used in the experiments. To induce morphine tolerance, a three-day cumulative dose regimen was used in the rats. Then, randomly selected rats were evaluated for morphine tolerance on day 4. The analgesic effects of hexarelin (0.2 mg.kg(-1)), [D-Lys3]-GHRP-6 (10 mg.kg(-1)), and morphine (5 mg.kg(-1)) were measured at 30-min intervals (0, 30, 60, 90, and 120 min) by tail-flick and hot-plate analgesia tests. The findings suggest that hexarelin in combination with morphine attenuates analgesic tolerance to morphine. On the other hand, ghrelin receptor antagonist [D-Lys3]-GHRP-6 has no significant analgesic activity on the morphine tolerance in analgesia tests. Furthermore, co-administration of hexarelin and morphine increases the analgesic effect. In condusion, these data indicate that administration of GHS-R agonist hexarelin with morphine enhances the antinociception and attenuates morphine tolerance.