FOXP3 rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population


ÇEKİN N. , PINARBAŞI E. , Bildirici A. E. , Donmez G., ÖZTEMÜR Z. , BULUT O. , ...More

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, vol.21, no.10, pp.1779-1786, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 10
  • Publication Date: 2018
  • Doi Number: 10.1111/1756-185x.13337
  • Title of Journal : INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
  • Page Numbers: pp.1779-1786

Abstract

Aim: Functional polymorphisms located in FOXP3 intron 1 was recently found to be associated with rheumatoid arthritis (RA). Although RA is an autoimmune disease, there is supporting evidence that activated maladaptive responses including pro-inflammatory pathways play roles in osteoarthritis (OA), similar to RA. The aim of this study was to explore the relationship between rs2232365 (-924A/G) and rs3761548 (-3279A/C) polymorphisms as well as possible changes in the 600 bp promoter region of FOXP3 and knee OA.