FOXP3 rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population


ÇEKİN N. , PINARBAŞI E. , Bildirici A. E. , Donmez G., ÖZTEMÜR Z. , BULUT O. , ...Daha Fazla

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, cilt.21, ss.1779-1786, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 10
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/1756-185x.13337
  • Dergi Adı: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
  • Sayfa Sayıları: ss.1779-1786

Özet

Aim: Functional polymorphisms located in FOXP3 intron 1 was recently found to be associated with rheumatoid arthritis (RA). Although RA is an autoimmune disease, there is supporting evidence that activated maladaptive responses including pro-inflammatory pathways play roles in osteoarthritis (OA), similar to RA. The aim of this study was to explore the relationship between rs2232365 (-924A/G) and rs3761548 (-3279A/C) polymorphisms as well as possible changes in the 600 bp promoter region of FOXP3 and knee OA.