Biosafety standards for working with Crimean-Congo hemorrhagic fever virus

Weidmann M., Avsic-Zupanc T., Bino S., Bouloy M., Burt F., Chinikar S., ...Daha Fazla

JOURNAL OF GENERAL VIROLOGY, cilt.97, ss.2799-2808, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 97
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1099/jgv.0.000610
  • Sayfa Sayıları: ss.2799-2808


In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.