DESIGN AND EVALUATION OF PROPOLIS-HPC/PVP ELECTROSPUN NANOFIBERS FOR POSSIBLE CUTANEOUS APPLICATIONS

Esentürk-Güzel I., ALĞIN YAPAR E., Cavalu S., ŞEKER İ. T., İNAL E., KARTAL M., ...Daha Fazla

Farmacia, cilt.72, sa.1, ss.200-213, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.31925/farmacia.2024.1.22
  • Dergi Adı: Farmacia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.200-213
  • Anahtar Kelimeler: biocompatibility, electrospinning, hdroxypropylcellulose, nanofibers, polyvinyl pyrollidone, propolis
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

The aim of the study was to prepare propolis loaded hydroxypropyl cellulose and polyvinyl pyrrolidone (HPC/PVP) nanofibers, suitable for cutaneous applications. LC-HRMS analyses were applied for the identification and quantification of the bio-compounds in the propolis extract. Electrospinning was applied in order to prepare propolis HPC/PVP nanofibers with increasing concentration of propolis 10%, 20% and 30 % (v/v) and subsequently characterized in terms of morphology, wettability, thermal degradation and biological properties. SEM images showed homogenous features of the nanofibers and average diameter between 197.2-268.4 nm, high antioxidant activity, very good biocompatibility and no cytotoxicity. Particularly, with the highest propolis concentration, 30-PE/HPC/PVP nanofiber formulation is a promising alternative to conventional treatments for cutaneous applications.