Cerebral Venous Sinus Thrombosis Presenting as Transient Ischemic Attacks in a Case With Homozygous Mutations of MTHFR A1298C and CG677T

Yildiz, ÖZLEM; ÇEVİK GÜNERİ, ŞEYDA; ÇİL, GÜLSÜM; ÖZTOPRAK, İBRAHİM; BOLAYIR, ERTUĞRUL; Topaktas, AHMET

doi:10.1016/j.jstrokecerebrovasdis.2010.03.010

Cerebral Venous Sinus Thrombosis Presenting as Transient Ischemic Attacks in a Case With Homozygous Mutations of MTHFR A1298C and CG677T

Atıf İçin Kopyala

Yildiz Ö., ÇEVİK GÜNERİ Ş., ÇİL G., ÖZTOPRAK İ., BOLAYIR E., Topaktas S.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, cilt.21, sa.1, ss.75-77, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 1
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.jstrokecerebrovasdis.2010.03.010
Dergi Adı: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.75-77
Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

We report a case with recurrent, transient attacks of slurred speech, weakness, and numbness of the right half of the face and the right arm without seizure activity, accompanied by headache and double vision. Neurologic examination revealed bilateral papilledema and right abducens palsy. Brain magnetic resonance imaging revealed thrombosis of the dural venous sinuses and the cortical veins, with no evidence of parenchymal lesion. Homozygous mutations were found for methylenetetrahydrofolate reductase (MTHFR) A1298C and MTHFR CG677T. Anticoagulation with heparin and warfarin resulted in prompt cessation of the transient attacks, as well as the signs and symptoms of increased intracranial pressure. This report documents that, although rare, transient ischemic attacks can result from cerebral venous thrombosis.