Akademik Veri Yönetim Sistemi
Journal of Molecular Structure, cilt.1356, 2026 (SCI-Expanded, Scopus)
In this study, novel nickel (II) phthalocyanines bearing functional groups with different atoms such as fluorine, sulfur, and oxygen, connected by oxygen bridges at their peripheral positions, were synthesized and characterized. The singlet oxygen generation, antioxidant, antibacterial activities, and cytotoxicity of the phthalocyanines (1a-4a) were systematically evaluated. The synthesized phthalocyanines exhibited solvent-dependent singlet oxygen generation, highlighting their potential as photosensitizers and providing valuable insights into their photochemical properties. Among the molecules, (1a) showed the highest reducing power activity, while (3a) displayed the strongest DPPH radical scavenging activity. Importantly, none of the studied molecules demonstrated toxicity toward HEK-293 cells, and all synthesized molecules showed antibacteriel activity against S. aureus. Furthermore, Gaussian computational studies were performed at the B3LYP, HF, and M062X levels with the 6–31++g(d,p) basis set. Molecular docking analyses were also carried out against zinc superoxide dismutase protein (PDB ID: 1CB4), Human peroxiredoxin 5 protein (PDB ID: 1H2D), and FabH Inhibitors proteins (PDB ID: 4Z8D).