Investigation of magnetic fluids in a chemometrically designed green microextraction method for determining chloramphenicol in fortified honey, milk and chicken meat

Bişgin A. T., ELİK A., ALTUNAY N.

Food Chemistry, cilt.492, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 492
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.foodchem.2025.145465
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Box-Behnken, CAP, Chemometric design, Chicken samples, Magnetic fluids, Milk
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A simple, green, magnet-assisted, cost-effective, and rapid analytical approach was presented for the reliable and accurate analysis of chloramphenicol (CAP) in dairy and chicken products. Magnetic fluids consisting of ionic liquids and deep eutectic solvents were prepared and, tested for the extraction of CAP from these samples using vortex-assisted dispersive magnetic fluid liquid-phase microextraction (VA-DMF-LPME) method. The critical variables of the VA-DMF-LPME method were optimized using Box-Behnken Design of Response Surface Methodology. VA-DMF-LPME method was validated, and satisfactory analytical data including preconcentration factor (150), low matrix effect (6.4 %), and short extraction time (below 125 s) were obtained. VA-DMF-LPME method exhibited a low limit of detection (0.3 ng mL−1) and excellent linearity in the range of 1–160 ng mL−1. Relative recoveries in real samples were 92.7–98.9 % with relative standard deviations ≤3.4 %. The results demonstrated that the VA-DMF-LPME method has high potential for future determination of CAP from different dairy and chicken samples.