GENE EXPRESSION LEVELS IN BRONCHIAL ASTHMA PATIENTS OF DUHOK POPULATION IN IRAQ


Issa H. Y. , Al-Habib O. A. M. , DURNA DAŞTAN S. , Ramadhan A. A. , Sevindik M., Selamoglu Z.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, pp.9036-9043, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2021
  • Title of Journal : FRESENIUS ENVIRONMENTAL BULLETIN
  • Page Numbers: pp.9036-9043
  • Keywords: Asthma, bronchitis, bronchial asthma, gene expression, qRT-PCR, IMMUNE, CELLS

Abstract

Bronchitis, asthma, allergy and bronchial asthma diseases are very common in these years. These diseases, which have increased with the age in the past, are nowadays frequently seen from very early ages and even from infancy. In addition. the frequency of these diseases varies according to different populations. It is suggested that environmental factors, genotypic structure of individuals have special effects or additive effects in these diseases which are also associated with the immune system not working effectively. The aim of our study is to determine the expression levels in some genes that are suggested to be related to these diseases in blood samples between the patient and control groups. In this study, gene expression values performed with the RT-PCR analysis are compared between brochititis-asthma patient group and control group by using 16 gene region. According to RTPCR gene expression analysis, individuals with bronchial-asthma have had remarkable increases or decreases in some gene regions. Some of these changes were found statistically significant.