Curcumin Attenuates Nonylphenol-Induced Toxicity In Brain Development; An Experimental Study


Suna P. A., Gergin O. O., BARAN M., ÜLGER M., GÖÇ R., YAY A. H.

Acta neurologica Taiwanica, cilt.32(3), ss.100-107, 2023 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32(3)
  • Basım Tarihi: 2023
  • Dergi Adı: Acta neurologica Taiwanica
  • Derginin Tarandığı İndeksler: Scopus, EMBASE
  • Sayfa Sayıları: ss.100-107
  • Anahtar Kelimeler: Curcumin, GFAP, Nonylphenol, p-tau brain development.
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Nonylphenol is an alkylphenol compound that has been widely used in the industry. It has endocrine-disrupting properties. The effect of alkylphenol compounds on development has been the subject of a limited number of studies. Herein, we aimed to examine curcumin's effect against nonylphenol toxicity on brain development. METHODS: For this study, 30 pregnant female Wistar albino rats from the Animal Laboratory of Erciyes University, Faculty of Medicine, were used. The rats were randomly divided into the following 5 groups; the control group, corn oil group (150μl/kg/day), nonylphenol group (50μl/kg/day), curcumin group (100mg/kg/day) and curcumin+nonylphenol group (100mg/kg/day+50 μl/kg/day). After the sacrification, histological and immunohistochemical evaluations were made. RESULTS: Histopathologically, vascular congestion, increased GFAP, and p-tau immunoreactivity intensity was found in the developing brain of the nonylphenol group. Moreover, co-treatment of nonylphenol administrated with curcumin showed slight pathological alterations with vascular congestion. CONCLUSIONS: These data suggest that nonylphenol-induced increase in GFAP and p-tau immunoreactivity contributes to toxicity caused impairment in the rat brain. Additionally, curcumin had a neuroprotective effect against nonylphenol-induced neurotoxicity.