Akademik Veri Yönetim Sistemi
Current Analytical Chemistry, cilt.19, sa.3, ss.262-271, 2023 (SCI-Expanded)
Background: Sertraline (ST) hydrochloride is an anti-depressant of the selective serotonin reuptake inhibitor (SSRI) class. Potentiometric sensors are an appealing route for detecting drugs due to some advantages in terms of sensitivity, feasibility, selectivity, fast response, tolerance to turbidity and colour of solutions, and cost-effectiveness. Methods: A mixture of polyvinyl chloride powder (PVC) with o-nitrophenyl octyl ether and the ion association complex was dissolved in tetrahydrofuran (THF) to prepare the membrane for the proposed sensor. The sensor was calibrated and then electrochemically used for detecting ST in pharmaceutical samples. Results: The near Nernstian response was observed for a concentration of 1.0 x 10-8-1.0 x 10-2 mol L-1 with 58.62 mV as a slope per concentration decade. This direct potentiometric measurement resulted in average recoveries of 96.0 ± 0.2%. Moreover, good selectivity for sertraline with respect to many inorganic and organic cations was observed. Conclusion: The proposed sensor was simple to use and produced accurate and precise results. The molecule's chemical and biological activities were revealed using theoretical calculations. Regarding the chemical activities, calculations were made on the 3-21g and 6-31g while the SDD bases were set at B3LYP, HF, and the M062X level. Molecular docking calculations were designed against cancer proteins in order to have details regarding the molecule's biological activity.