An anticancer drug loading and release study to ternary GO-Fe3O4-PPy and Fe3O4 @PPy-NGQDs nanocomposites for photothermal chemotherapy

ATİLA DİNÇER C., Getiren B., Gokalp C., ÇIPLAK Z., KARAKEÇİLİ A., YILDIZ N.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, cilt.633, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 633
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.colsurfa.2021.127791
  • Dergi Adı: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chimica, Compendex, EMBASE, INSPEC
  • Anahtar Kelimeler: GO-Fe3O4-PPy, Fe3O4 @PPy-NGQDs, Doxorubicin (DOX), NIR, Photothermal chemotherapy, Drug release, FACILE SYNTHESIS, NANOPARTICLES, THERAPY, DOXORUBICIN, DELIVERY, OXIDE, CELLS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Photothermal therapy (PTT) is a new treatment method being developed against traditional cancer therapy methods. In this study, graphene oxide-iron oxide-polypyrrole (GO-Fe3O4-PPy) and iron oxide@polypyrrolenitrogen doped graphene quantum dots (Fe3O4 @PPy-NGQDs) ternary nanocomposites having superior photo thermal and magnetic properties were loaded with doxorubicin (DOX) anticancer drug. The loading and release of the DOX was investigated by UV-visible spectroscopy. At the end of 48 h, the cumulative release of DOX from GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX at pH 5.5 and pH 7.4 was obtained as 99.55% +/- 0.20, 48.87% +/- 0.20% and 97.88% +/- 0.45, 38.82% +/- 0.26, respectively. After a short period of time like 4 h and 8 h, NIR-triggered release of DOX was increased significantly compared to drug release without NIR. The cytotoxic effects on the 4T1 mouse breast cancer cells of GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX drug loaded nanocomposites were determined by MTT test. The increase of DOX release with NIR effect was demonstrated by both in-vitro cytotoxicity studies and confocal laser microscopy images. In summary, multifunctional GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX nanocomposites have great potential for photothermal chemotherapy.