Effects of Rumex patientia L. extract on some drug-metabolizing enzymes in rat liver


Silig Y. , Cetinkaya O., Demirezer L.

INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, cilt.41, ss.45-47, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 41 Konu: 1
  • Basım Tarihi: 2004
  • Dergi Adı: INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
  • Sayfa Sayıları: ss.45-47

Özet

The effect of aqueous extract from the roots of Rumex patientia L. (Polygonaceae) (D-1), a traditional Turkish medicine used as a laxative and cholagogue, on drug-metabolizing enzymes, such as cytochrome P4502E1, NADPH cytochrome c reductase, NADH cytochrome b(5) reductase and glutathione-S-transferase (GST); and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were studied in male Wistar albino rat liver. A significant increase was observed in cytochrome P4502E1 and GST activities, but not in NADPH-cytochrome c reductase and NADH-cytochrome b(5) reductase activities. Serum AST and ALT activities were found within the normal laboratory range values. The results demonstrated that the aqueous extract of R. patientia triggers induction of cytochrome P4502E1 in liver and cytosolic GST activity.