Lu, Sm, and Y-based double-decker phthalocyanines with enhanced photodynamic therapy performance

Zeki K., YABAŞ E., Erden F., SALİH B., CANLICA M.

Polyhedron, cilt.261, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 261
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.poly.2024.117138
  • Dergi Adı: Polyhedron
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica
  • Anahtar Kelimeler: Double-decker phthalocyanines, Photodynamic therapy, Photosensitizer, Rare earth metals, Singlet oxygen
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

This paper focuses on the preparation of 3,5-di-tert-butylphenoxy substituted Lu, Sm, and Y-based double-decker phthalocyanines (Pcs), and investigation of their PDT properties. Briefly, 1,8,15,22-tetra-(3,5-di-tert-butylphenoxy) bisphthalocyanine derivatives (denoted LuPc2-3, SmPc2-4, YPc2-5) were synthesized by a two-step process. First, metal-free 1,8,15,22-tetra-(3,5-di-tert-butylphenoxy)phthalocyanine was prepared by tetramerization of 3,5-di-tert-butylphenoxy phthalonitrile, which is followed by reaction of different lanthanide salts with 1,8,15,22-tetra-(3,5-di-tert-butylphenoxy)bisphthalocyanine. The resultant double-decker Pcs were characterized in detail by UV–Vis, FT-IR, 1H NMR, fluorescence spectroscopy, MALDI-TOF MS, and elemental analysis. Strikingly, we report that double-decker phthalocyanines are not only photostable, but also exhibit relatively high singlet oxygen quantum yields of 0.96 (LuPc2-3), 0.91 (SmPc2-4) 0.87 (YPc2-5) and in THF.