Determination of Mirtazapine and Desmethyl Mirtazapine in Human Plasma by a New Validated HPLC Ultraviolet Method with a Simple and Reliable Extraction Method: Application to Therapeutic Drug Monitoring Study by 62 Real Patient Plasma


DURAL E. , Baskak N. S. , Ozcan H., Kir Y., BASKAK B., SÜZEN H. S.

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol.19, no.1, pp.18-30, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.22037/ijpr.2019.14599.12519
  • Title of Journal : IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
  • Page Numbers: pp.18-30

Abstract

Determination of mirtazapine (MRP) during psychopharmacotherapy in biological fluids is essential to achieve successful therapy, to avoid toxicity related to drug interactions, genetic variability, and poor compliance. A new, rapid, and sensitive high-performance liquid chromatography method has been developed in human plasma for the determination of MRP and N-desmethylmirtazapine (NDM) that is an active metabolite.