Effects of zeolite have been described on the biochemical parameters of blood of Cyprinus carpio exposed to copper sulphate. The control fish showed 57.67% increase in body weight over a period of 90 days. This increase was 26.45% after exposure to copper sulphate (2mg/L) and 32.01% after Zeolite treatment (60 mg/L). When Zeolite was administered along with copper sulfate the fish showed 46.24% increase in body weight. Blood sampling were made for the determination of hematological values (glucose (GLU), blood urea nitrogen (BUN), total protein (TP), albumin (ALB), globulin (GLB), creatinine (CR), total bilirubin (TBIL), uric acid (UA), and direct bilirubin (DBIL)) at 30, 60, 90 days. Fish weight increased 26.45%, 46.29%, 32.01% and 57.67% respectively in groups and differences between groups were significant (p<0.05). GLU, BUN, TP, ALB, GLB, CR, TBIL and UA yalues differed significantly among the groups (P<0.05). There were significant differences GLU, BUN, TP, ALB, GLB, CR, TBIL and UA values among the groups (P<0.05). TP value decreased, but GL, TBIL, UA and DBIL values of CuSO4 group increased significantly compared to control group (p<0.05). Therefore, it was suggested to use of clinoptilolite in rearing waters when there is a problem related to metals.