Clinical Characteristics, Lesion Distribution, and Systemic Comorbidities in Patients With Oral Lichen Planus

Eninanç İ., Yalçın D.

JOURNAL OF ORAL PATHOLOGY AND MEDICINE, cilt.0, ss.1-10, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 0
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1111/jop.70192
  • Dergi Adı: JOURNAL OF ORAL PATHOLOGY AND MEDICINE
  • Derginin Tarandığı İndeksler: Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1-10
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: This cross-­ sectional study aimed to comprehensively evaluate clinical forms, anatomical location, symptoms, sys-

temic comorbidities, and potentially relevant factors in patients with oral lichen planus (OLP).

Methods: Seventy-­ two patients with histopathologically confirmed OLP were included. Awareness of the disease, clinical forms,

lesion location, and symptoms and their relationships were investigated. Smoking and alcohol consumption, and the presence

of adjacent prosthetic or restorative materials were evaluated as potentially relevant factors. The prevalence of systemic diseases

was assessed.

Results: The reticular form was the most frequent clinical presentation, followed by plaque-­ like and erosive forms. Lesions were

most commonly localized on the buccal mucosa, followed by the tongue and the gingiva. The reticular form was most frequently

observed on the buccal mucosa and tongue (p=0.001). The combination of the reticular and erosive forms was most frequently

observed on the buccal mucosa (p=0.001), whereas the combination of the reticular and plaque-­ like forms was more com-

monly observed on the buccal mucosa and tongue. The erosive form was associated with more prominent symptoms (p=0.003,

p=0.001). The most frequent systemic comorbidities were hypertension, diabetes, and hypothyroidism. No significant differ-

ences were observed in systemic diseases, symptoms, or relevant factors between sexes.

Conclusions: Clinical forms of OLP may coexist within the same patient and, in some cases, within the same lesion. The most

common combination was the coexistence of the reticular form with plaque-­ like or erosive forms. The erosive form is sympto-

matic. Systemic comorbidities were also commonly observed among patients with OLP, warranting attention during clinical

evaluation.