Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats


Benzer F., KANDEMİR F. M. , ÖZKARACA M. , KÜÇÜKLER S., Caglayan C.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol.32, no.2, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1002/jbt.22030
  • Title of Journal : JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Keywords: apoptosis, cardiotoxicity, curcumin, doxorubicin, inflammation, CHRYSIN PROTECTS, KAPPA-B, STRESS, ANTIOXIDANT, TOXICITY, CARDIOMYOPATHY, NEPHROTOXICITY, NEPHROPATHY, DISEASE, CANCER

Abstract

Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. The present study aimed to assess the ameliorative effect of curcumin against DXR-induced cardiotoxicity in rats. Rats were subjected to oral treatment of curcumin (100 and 200mg/kg body weight) for 7 days. Cardiotoxicity was induced by single intraperitoneal injection of DXR (40mg/kg body weight) on the 5th day and the rats sacrificed on 8th day. Curcumin ameliorated DXR-induced lipid peroxidation, glutathione depletion, decrease in antioxidant (superoxide dismutase, catalase, and glutathione peroxidase) enzyme activities, and cardiac toxicity markers (CK-MB, LDH, and cTn-I). Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-, and interleukin-1, and cardiac tissue damages that were induced by DXR. Moreover, curcumin decreased the expression of 8-OHdG and 3,3-dityrosine. This study demonstrated that curcumin has a multi-cardioprotective effect due to its antioxidant, anti-inflammatory, and antiapoptotic properties.