The Effect of Methylphenidate Treatment on Olfactory Function in Children and Adolescents With ADHD

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Mercan Isik C., Uzun Çiçek A., Altuntaş E. E., Bora A., Sarı S. A., Akkuş S.

Journal of Attention Disorders, cilt.27, sa.10, ss.1107-1116, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1177/10870547231171727
  • Dergi Adı: Journal of Attention Disorders
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CINAHL, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.1107-1116
  • Anahtar Kelimeler: child, adolescent, ADHD, methylphenidate, odor function, sniffin' sticks
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to research whether there is an olfactory disorder in ADHD, and if so, what is the effect of methylphenidate on this condition. Method: This is a cross-sectional study aiming to evaluate olfactory threshold, identification, discrimination and threshold, discrimination, and identification (TDI) scores in 109 children and adolescents, 33 of whom have ADHD without medication, 29 with ADHD with medication and 47 control groups. Result: In the post hoc tests, the mean odor discrimination test, the mean odor identification test, and the mean TDI scores of the unmedicated ADHD group were significantly lower than those of the other two groups, and that the mean odor threshold test scores of the medicated ADHD group were significantly lower than those of the control and unmedicated groups. Conclusion: Olfactory function could be a useful tool to monitor treatment effects and may be a promising candidate as a biomarker in ADHD.