Gustave Roussy Immune Score in Operable Pancreatic Ductal Adenocarcinoma: Its Association with Quantitative 18F-FDG PET/CT Parameters and Histopathological Features, and Prognostic Significance

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Şeker K., Koç S., Özer H., Hasbek Z.

TURK ONKOLOJI DERGISI, cilt.40, sa.4, ss.283-292, 2025 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5505/tjo.2025.4687
  • Dergi Adı: TURK ONKOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Scopus, Emerging Sources Citation Index (ESCI), CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.283-292
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

OBJECTIVE
This study aimed to investigate the relationship and prognostic value of the Gustave Roussy Immune Score (GRIm Score), quantitative 18F-FDG PET/CT parameters, and histopathological features in operable pancreatic ductal adenocarcinoma (PDAC) patients.

METHODS
We retrospectively analysed 18F-FDG PET/CT data, routine pre-operative blood tests (for GRIm Score), and post-surgical pathology (LVI, PNI, etc.) from 41 operable PDAC patients (2016-2024). The GRIm Score (0-3) was determined using LDH, Albumin, and NLR. Patients were categorized into low (0-1) and high (2-3) GRIm groups for statistical evaluation.

RESULTS
No significant correlation was found between the GRIm score and PET/CT or pathology features. Mean overall survival was 12.97 months. Patients with high GRIm scores showed significantly shorter survival (6.2 months vs. 16.7 months, p<0.001). Multivariate survival analysis confirmed that both the GRIm score (HR=10.258, p<0.001) and the presence of LVI (HR=14.899, p=0.019) were independent prognostic factors. Other parameters did not show a significant association with survival.

CONCLUSION
The GRIm score, easily and cost-effectively calculated from routine blood tests, holds significant and independent prognostic value in operable PDAC patients. Its independence from conventional tumor features suggests promising potential for assessing prognosis.Keywords : 18F-FDG PET/CT; GRIm score; histopathology; pancreatic ductal adenocarcinoma; survival