Investigation of the Presence of Sildenafil in Herbal Dietary Supplements by Validated HPLC Method


DURAL E.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, ss.56-62, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2018.91249
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.56-62

Özet

Objectives: As the first FDA-approved phosphodiesterase type 5 inhibitor, sildenafil (SDF) is widely used in the treatment of erectile dysfunction due to its strong pharmacodynamic activity. Since many food supplements are now involved in illegal adulteration, the presence of SDF in food supplements is very important because of their toxicological risks. In this study a simple fast, reliable high-performance liquid chromatography method with ultraviolet (UV) detector has been developed and validated for SDF analysis in herbal dietary supplements (HDSs).