Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle

Toker M., BAĞÇİVAN İ., TOPALKARA A., KARADAŞ B., DURMUŞ N., PARLAK A., ...Daha Fazla

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.24, sa.6, ss.537-541, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1089/jop.2007.0129
  • Dergi Adı: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.537-541
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant effects of celecoxib, DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone), and indomethacin, cyclo-oxygenase (COX-1 and -2) inhibitors, in the absence or presence of a nifedipine, L-type Ca2+ channel blocker, on bovine ciliary muscle.