Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA 1H-Benzimidazol türevlerinin sentezi ve DNA ile etkileşimlerinin voltametrik tayini


Alpan A. S. , Yilmaz O., Kilickaya O. , Kara P., Gunes H. S. , Ozsoz M. S.

Marmara Pharmaceutical Journal, vol.16, no.1, pp.48-55, 2012 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.12991/201216420
  • Title of Journal : Marmara Pharmaceutical Journal
  • Page Numbers: pp.48-55

Abstract

In this study, synthesis and determination of interaction between DNA and 1H-benzimidazole derivatives has been performed by using electrochemical genosensor technology. Detection of DNA - drug interaction mechanism relies on monitoring Differential pulse voltammetric (DPV) responses of drugs at disposable graphite electrodes (DGEs). Interaction of 7 different benzimidazole derivates between double-stranded (ds) and single-stranded (ss) DNA were observed by changing the voltammetric signals of drugs at the detection limits of 0.62 nM of compound 1, 1.23 nM of 2, 1.26 nM of 3, 1.08 nM of 4, 1.13 nM of 5, 0.69 nM of 6 and 0.42 nM of 7, respectively.