Trends of primary glomerular disease in Turkey: TSN-GOLD registry report

Gul C. B., Kucuk M., Ozturk S., Demir E., EREN N., Sumnu A., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.54, sa.9, ss.2285-2294, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11255-022-03123-6
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database, MEDLINE
  • Sayfa Sayıları: ss.2285-2294
  • Anahtar Kelimeler: IgA nephropathy, FSGS, Kidney biopsy registry, Primary glomerulopathy, RENAL BIOPSY, PRIMARY GLOMERULONEPHRITIS, SPANISH REGISTRY, IGA NEPHROPATHY, EPIDEMIOLOGY, FREQUENCY, ADULTS, PREVALENCE, NATIONWIDE, DIAGNOSIS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. Results A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (x 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (x 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.