Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever
PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.34, sa.8, 2015 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 8
- Basım Tarihi: 2015
- Doi Numarası: 10.1097/inf.0000000000000706
- Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection.