Important of Angiopoietic System in Evaluation of Endothelial Damage in Children with Crimean-Congo Hemorrhagic Fever


SANCAKDAR E. , Guven A. S. , UYSAL E. B. , DEVECİ K. , GÜLTÜRK E.

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.34, 2015 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 34 Konu: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/inf.0000000000000706
  • Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL

Özet

Background: Crimean-Congo hemorrhagic fever (CCHF) causes endothelial activation and dysfunction by affecting the endothelium directly or indirectly. In maintaining the vascular integrity, vascular endothelial growth factor (VEGF-A) and its receptor (VEGFR1) and angiopoietin-2 (Ang-2) and its receptor (Tie-2) are very important mediators. For this reason, we aimed at studying the association of Ang-2 and VEGF and their receptors Tie-2 and VEGFR1 with CCHF infection.