Purpose This study was conducted to evaluate the effect of a solution-oriented approach in depressive patients on suicide probability and the social functioning level. Design and Method The research was designed as a randomized controlled trial with a pretest and posttest control group and repeated measures. A Solution-Oriented Approach Intervention (SOAI) was performed for a total of 6 to 10 sessions with the experimental group. Findings The SOAI in depressive patients effectively increased the social functioning level and decreased suicide probability. Practice Implications The SOAI in depressive patients should be implemented by psychiatric nurses within the scope of psychiatric care services.