How do arbidol and its analogs inhibit the SARS-CoV-2?

Aktas A., Tuzun B., Kafa T. A. H., Sayin K., Ataseven H.

Bratislavske lekarske listy, cilt.121, sa.10, ss.705-711, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 121 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4149/bll_2020_115
  • Dergi Adı: Bratislavske lekarske listy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.705-711
  • Anahtar Kelimeler: SARS-CoV-2, spike glycoprotein, hemagglutinin esterase, arbidol, in silico, VIRUS, SPIKE, DOCKING, PROTEIN, GLIDE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

BACKGROUND: COVID-19 is not fully known and causes severe inflammation and cytokine storm. It has many symptoms, such as: fever, sore throat, headache, dyspnoea, and diarrhoea. Arbidol was used in the treatment of COVID19, which was the most critical health problem in the world. However, the desired recovery was not achieved with Arbidol. Many countries still use this drug in the treatment of COVID19.