A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives

Ahmadi Shourkaei F., Rashidi Ranjbar P., Mahdavi M., TÜZÜN B., Taslimi P.

Iranian Journal of Chemistry and Chemical Engineering, cilt.43, sa.3, ss.1103-1114, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.30492/ijcce.2023.2000101.5969
  • Dergi Adı: Iranian Journal of Chemistry and Chemical Engineering
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1103-1114
  • Anahtar Kelimeler: 2-Thioxoquinazolin-4(1H)-one Derivative, ADME/T, Breast cancer, Cyclization reaction, Liver cancer, Molecular docking
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A facile synthetic route for constructing 2-thioxoquinazolin-4(1H)-one derivative through cyclization reactions using readily available starting materials 2-aminobenzoic acids, alkyl/aryl amines, and carbon disulfide is described. These reactions occur under mild conditions, producing the desired products with good to high yields. Molecular docking was conducted to assess the activities of the 2-thioxoquinazolin-4(1H)-one derivative against breast cancer protein (PDB ID: 1JNX), liver cancer protein (PDB ID: 2H80), and colon cancer protein (PDB ID: 4UYA). Furthermore, an ADME/T analysis was performed to evaluate the impact of these compounds on human metabolism.