Synthesis and biological evaluation of novel indenopyrazole derivatives

Gezegen H., Tutar U., Hepokur C., Ceylan M.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.33, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/jbt.22285
  • Dergi Adı: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: 2-Benzoylindan-1-one, anticancer, antimicrobial, apoptosis, indenopyrazole, KINASE INHIBITORS, CELECOXIB ANALOGS, DESIGN, PYRAZOLE, AGENTS, REPLACEMENT, SULFONAMIDE, DISCOVERY, INSIGHT, AMIDES
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A series of novel indenopyrazole derivatives 2a-j and 3a-j were synthesized from the reaction of 1-(4-(hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea derivatives 1a-j with hydrazine and phenylhydrazine, respectively. The obtained novel indenopyrazoles (2a-j and 3a-j) were evaluated for anticancer activity against HeLa and C6 cell lines. Antiproliferative activity was determined by the BrdU proliferation ELISA assay; 2a, 2b, 2d, 2h, and 3h were found to be the most active compounds. The compounds were also screened for antimicrobial activity, and all compounds showed moderate activity against used microorganisms.