Akademik Veri Yönetim Sistemi
EUROPEAN ORAL RESEARCH, cilt.58, sa.1, ss.22-29, 2024 (ESCI)
Abstract
Purpose: The aim of this study is to compare the biocompatibility of two different resin
composites after polymerization under two different light sources in three different time
periods.
Materials and Methods: 72 polyethylene tubes polymerized with 2 different resin
composites and 2 different light sources (Elipar S10 and Valo ) [Group 1: Kalore Elipar S10
(KE), Group 2: Kalore Valo (KV), Group 3: Essentia Elipar S10 (EE), Group 4: Essentia Valo
(EV)] were implanted in the dorsal connective tissue of 18 rats. 24 empty polyethylene tubes
[Group 5: (Control group)] were implanted in the dorsal connective tissue of 6 rats. Then, the
rats were sacrificed after 7th, 15th and 30th days in each time intervals (n=8). Biopsy samples
were stained with H&E and examined for inflammation, necrosis, macrophage infiltrate, giant
cell and fibrous capsule criteria. Immunohistochemical staining was performed to evaluate
proinflammatory cytokines (IL-1β, IL-6 and IL-8).
Results: When the composite groups and the control groups were compared; there was
difference statistically significant for the criteria of inflammation at 7th and 15th days, there
was no statistical difference between the time points in terms of fibrous capsule and necrosis.
When the composite groups and control groups were evaluated in terms of proinflammatory
cytokines; statistically significant differences were found at 7th, 15th and 30th days.
This article has been accepted for publication and undergone full peer review but has not been
through the copyediting, typesetting, pagination and proofreading process, which may lead to
differences between this version and the Version of Record
Conclusion: All CRs used in this study showed acceptable biocompatibility in the
subcutaneous tissues of rats after polymerization with different light sources.
Keywords: composite resins, light sources, biocompatibility, rat, immunohistochemi