Akademik Veri Yönetim Sistemi
International Journal of Academic Medicne and Pharmacy, cilt.4, sa.1, ss.13-18, 2022 (Hakemli Dergi)
Abstract: Temporal lobe epilepsy (TLE) is the most common focal epileptic syndrome in population. Mesial
temporal sclerosis (MTS) is a frequent structural abnormality in medically intractable TLE. In this study, we aimed
quantitative evaluation of epileptogenic focus using interictal diffusion-weighted magnetic resonance imaging
(MRI) method in patients with temporal lobe epilepsy. A total of 72 TLE patients who underwent cranial MRI and
35 control cases were included in this study. 34 hippocampal sclerosis (HS) patients and 38 normal patients were
evaluated. Patients were divided into two subgroups as MTS+ and MRI-negative TLE. The measurements of ADC
were obtained from the hipocampus head, corpus, tail, amygdala, temporal lobe white matter and cortex bilaterally
in the axial ADC map and compared between the groups. In the MTS group, predictive cutoff levels of hippocampal
ADCs for identifying pathologic areas were established through receiver operating characteristic (ROC) curve analysis. MTS + group had significantly higher ADC values compared to control group, MTS-negative TLE group and
contralateral side (p<0.05). We obtained significantly higher ADCs in right hippocampus corpus and tail, left
temporal lobe cortex in MRI-negative TLE group than the contralateral side (p<0.05).