Poly(ethylene oxide)-Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar E., İNAL Ö.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, vol.11, no.5, pp.855-866, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 11 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.4314/tjpr.v11i5.20
  • Journal Name: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.855-866
  • Keywords: PEO-PPO based copolymer, Poloxamer, Hydrogel, Transdermal, Drug delivery, VIVO SKIN PERMEATION, PLURONIC F-127 GELS, BLOCK-COPOLYMER, AQUEOUS-SOLUTION, POLOXAMER GEL, PHYSICOCHEMICAL CHARACTERIZATION, PERCUTANEOUS-ABSORPTION, 5-AMINOLEVULINIC ACID, ASSOCIATION BEHAVIOR, MICELLE FORMATION
  • Sivas Cumhuriyet University Affiliated: No

Abstract

Amphiphilic poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO)-based copolymers are thermoresponsive materials having aggregation properties in aqueous medium. As hydrosolubilizers of poorly water-soluble drugs and improved stability of sensitive agents, these materials have been investigated for improvement in solubility, stability, release and bioavailability of drugs. The goal of the present review is to summarize the properties of PEO-PPO based copolymers and highlight the works that have been carried out on these materials for transdermal drug delivery.