Tumors Metastasizing to the Central Nervous System
Approaches to Metastatic Tumors in Pathology, NOVA Publications , ss.59-76, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.59-76
- Anahtar Kelimeler: blood-brain barrier, brain metastasis, neuropathology, neuroradiology
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
The most common intracranial malignancy in adults is brain metastasis, occurring in approximately 30% of patients with a primary malignancy. Some cases may present with an unknown primary site. The most frequent sources of brain metastasis are lung and breast carcinomas, as well as melanoma. The presence of brain metastasis is typically identified through neuroradiological imaging, with computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET/CT) being the most commonly employed techniques. Central nervous system symptoms may indicate the possibility of brain metastasis, but the definitive diagnosis is made through histopathological examination, which remains the gold standard. Immunohistochemical and molecular analyses play crucial roles in pathological evaluation. There is ongoing debate regarding the optimal treatment approach for patients with brain metastases. The most common treatment modality is neurosurgery, although radiotherapy and chemotherapy are also viable options. Prompt detection of brain metastasis, a known indicator of poor prognosis, is crucial for effective treatment. Therefore, routine cranial imaging is considered important for patient management. Enhancing awareness and collaboration among related clinical disciplines, as well as further elucidating the mechanisms of brain metastasis formation, will be key to improving patient management.