Akademik Veri Yönetim Sistemi
Türk Beyin Damar Hastalıkları Dergisi, cilt.28, sa.3, ss.165-171, 2022 (Hakemli Dergi)
INTRODUCTION: Certain female sex specific factors (SSFs) including pregnancy, puerperium and oral contraceptive (OC) use have been associated with cerebral venous thrombosis (CVT). We aimed to determine if there are differences between female patients with and without SSFs regarding the clinical characteristics, neuroimaging findings and the prognosis of CVT. METHODS: This is a retrospective study that included consecutive female inpatients with CVT admitted to our hospital between January 1, 2012 and December 31, 2021. The demographic and clinical characteristics, neuroimaging findings and the outcome data were collected from the patient files. RESULTS: Fifty-three female patients were included into the study. Thirty-one (58.5%) of the patients had SSFs including pregnancy (n=2), puerperium (n=20), and OC use (n=9). The mean age of patients with SSFs was lower than that of the patients without SSFs (30.7 and 44.0, respectively, p=0.002). The mode of disease onset, clinical manifestations, epileptic seizures, parenchymal lesions, thrombosed veins, length of hospital stay did not differ between the patients with and without SSFs. Predisposing factors, including cancer, were more common in the patients without SSFs. The median of the modified Ranskin scale score of the patients with SSFs was lower than that of the patients without SSFs. The OC users were older and had a more slow disease onset than the postpartum patients. All patients were treated with anticoagulants, decompressive surgery was performed in one patient. DISCUSSION AND CONCLUSION: The majority of the female CVT patients had SSFs, most commonly puerperium. The mean age is lower and prognosis is better in the patients with SSFs.