Can Peritoneal Cancer Index be Determined in 18F-FDG PET/CT Before Surgery in Ovarian Peritoneal Carcinomatosis?

Turkan H., Karabacak U., Coskun G., HASBEK Z., Karadayi K.

Indian Journal of Gynecologic Oncology, cilt.23, sa.3, 2025 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s40944-025-01020-1
  • Dergi Adı: Indian Journal of Gynecologic Oncology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: 18F-FDG PET/CT, Ovarian carcinomatosis, Peritoneal cancer index (PCI), Peritoneal carcinomatosis, Tubo-ovarian cancer
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: This study aimed to evaluate the accuracy and reliability of preoperative 18F-FDG PET/CT in predicting the peritoneal cancer index (PCI) in patients diagnosed with peritoneal carcinomatosis secondary to ovarian cancer. Methods: Thirty patients with ovarian cancer (FIGO stages IIIC to IV) who underwent preoperative 18F-FDG PET/CT imaging at our institution were included. The surgical peritoneal cancer index (sPCI) was statistically compared with the radiological PCI (rPCI) derived from preoperative 18F-FDG PET/CT scans. Results: Statistical analysis revealed significantly lower predictive values for rPCI compared to sPCI (p = 0.013). Subgroup analysis demonstrated no statistically significant difference between sPCI and rPCI in patients with sPCI ≤ 10 (p = 0.096). Conclusions: Our findings suggest that 18F-FDG PET/CT has limited utility in predicting the peritoneal cancer index in ovarian carcinomatosis. However, it may be clinically reliable in cases where the radiological PCI is < 10.