The Effects of Intravenous Ephedrine During Spinal Anesthesia for Cesarean Delivery: A Randomized Controlled Trial


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ÖZDEMİR KOL İ. , Kaygusuz K. , Gursoy S., ÇETİN A. , Kahramanoglu Z., Ozkan F., ...Daha Fazla

JOURNAL OF KOREAN MEDICAL SCIENCE, cilt.24, ss.883-888, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3346/jkms.2009.24.5.883
  • Dergi Adı: JOURNAL OF KOREAN MEDICAL SCIENCE
  • Sayfa Sayıları: ss.883-888

Özet

We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 mg/kg intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/kg lactated Ringer's solution was given. Shortly after the spinal injection, ephedrine 0.5 mg/kg or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower incidences of hypotension and nausea and vomiting in the ephedrine group compared with the control group (8 [38.1%] vs. 18 [85.7%]); (4 [19%] vs. 12 [57.1%], respectively) (P<0.05). The first rescue ephedrine time in the ephedrine group was significantly longer (14.9 +/- 7.1 min vs. 7.9 +/- 5.4 min) than that of the control group (P<0.05). Neonatal outcome were similar between the study groups. These findings suggest, the prophylactic bolus dose of 0.5 mg/kg intravenous ephedrine given at the time of intrathecal block after a crystalloid fluid preload, plus rescue boluses reduce the incidence of hypotension.