APRACLONIDINE AND CLONIDINE - A COMPARISON OF EFFICACY AND SIDE-EFFECTS IN NORMAL AND OCULAR HYPERTENSIVE VOLUNTEERS


YUKSEL N., GULER C., CAGLAR Y., ELIBOL O.

INTERNATIONAL OPHTHALMOLOGY, cilt.16, ss.337-342, 1992 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1007/bf00917987
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Sayfa Sayıları: ss.337-342

Özet

We performed a prospective, randomized double blind study comparing the cardiovascular and intraocular pressure (IOP) effects of unilateral therapy with clonidine 0.125% and apraclonidine hydrochloride 1.0% in 15 normal and 15 ocular hypertensive volunteers. Baseline values were obtained prior to instillation. One drop of test medication (clonidine, apraclonidine or placebo) was instilled unilaterally, and the postinstillation measurements were taken at 1, 2, 4, 6 and 8 hours. Apraclonidine 1% produced a maximum 31.4% +/- 6.9% (4.83 +/- 1.17 mmHg) decrease in mean IOP in ocular normotensive volunteers and 33.9% +/-6.9% (10.10 +/- 2.45 mmHg) in ocular hypertensive patients (p < 0.001).