KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients
CANCER BIOMARKERS, cilt.17, sa.2, ss.133-143, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2
- Basım Tarihi: 2016
- Doi Numarası: 10.3233/cbm-160624
- Dergi Adı: CANCER BIOMARKERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.133-143
- Anahtar Kelimeler: Colorectal cancer, hypermethylation, oncogene, tumor suppressor gene, KRAS, BRAF, SFRP2, DAPK1, MGMT, HIC1, p16, GROWTH-FACTOR RECEPTOR, CPG ISLAND METHYLATION, NORMAL COLONIC-MUCOSA, K-RAS MUTATIONS, DNA METHYLATION, ASSOCIATION, POPULATION, CETUXIMAB, SURVIVAL, STAGE
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes cause colorectal cancer development. Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis.