KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients


BAĞCI B. , SARİ M. , KARADAYI K. , TURAN M. , ÖZDEMİR Ö., BAĞCI G.

CANCER BIOMARKERS, cilt.17, ss.133-143, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3233/cbm-160624
  • Dergi Adı: CANCER BIOMARKERS
  • Sayfa Sayıları: ss.133-143

Özet

BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes cause colorectal cancer development. Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis.