Chronic obstructive pulmonary disease (COPD) with life-threatening features due to uncomfortable symptoms such as dyspnea decreases satisfaction with life. This study aims to determine the effect of religious coping methods on satisfaction with life in patients with COPD in Turkey. This descriptive and cross-sectional study was conducted with patients who had COPD for at least a year (n = 149). The positive religious coping levels of the patients were high while their negative religious coping levels were low and their levels of satisfaction with life were below average. A positive correlation was found between the positive religious coping levels and satisfaction with life of the patients (p < 0.05). The patients' age, general health levels, economic status, state of meeting their daily needs and usage of positive religious coping were the factors that significantly affected their levels of satisfaction with life, and these factors explained 38% of the total variance in the patients' satisfaction with life. It is important to evaluate religious coping in increasing the satisfaction with life of COPD patients who receive treatment in health institutions.