Evaluation of Subclinical Inflammation in Children with Premature Adrenarche

Koylu G., ÇELİK N., DOĞAN H. O.

ERCIYES MEDICAL JOURNAL, cilt.44, sa.6, ss.603-607, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14744/etd.2022.39699
  • Dergi Adı: ERCIYES MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.603-607
  • Anahtar Kelimeler: Fetuin-A, highly sensitive c-reactive protein, inflammation, interleukin-6, premature adrenarche, METABOLIC SYNDROME, PRECOCIOUS PUBARCHE, GIRLS, HISTORY, HYPERINSULINEMIA, SENSITIVITY, INDEX, RISK
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: The objectives of this study were to compare the serum inflammatory markers, interleukin-6 (IL-6), highly sensi-tive C-reactive protein (hs-CRP), and fetuin-A, in patients with premature adrenarche (PA) and the control group.Materials and Methods: This single-center cross-sectional study included 85 non-obese and pre-pubertal children. After 8-12 h of fasting, blood glucose, HDL, LDL, triglyceride, cholesterol, insulin, dehydroepiandrosterone sulfate, total testos-terone, 17-OH PG, IL-6, hs-CRP, and Fetuin-A levels were measured and compared in a convenience sample of PA (n=35) and a healthy volunteers of control (n=50) group.Results: The mean age (7.34 +/- 0.62 years vs. 7.09 +/- 0.77 years, respectively) and sex (82% girl vs. 80% girl, respectively) of the PA and control groups were similar (p>0.05). Fasting insulin levels (10.9 +/- 6.21 Uu/mL vs. 7.4 +/- 5.9 Uu/mL; p<0.001), HOMA-IR (2.06 +/- 0.63 vs. 1.36 +/- 1.00; p=0.017), FGIR (11.31 +/- 5.60 vs. 16.46 +/- 8.52; p=0.004), and QUICKI (0.35 +/- 0.02 vs. 0.37 +/- 0.03; p<0.001) levels were different in PA and control groups. IL-6 level higher in PA group than controls [2.7 (3.30) pg/mL vs. 3.02 (1.31) pg/mL, p=0.035], while plasma Fetuin-A [522.02 (715.86) mg/L; 519.4 (945.97) mg/L, p=0.434] and hs-CRP [0.73 (1.02) mg/dL; 1.0 (1.12) mg/dL, p=0.439] levels were similar. IL-6 cutoff value for PA was calculated as 2.06 with 72.7% sensitivity and 48.8% specificity for all study groups (AUC=0.641, p=0.036). Conclusion: The high IL-6 levels may be an indicator of chronic subclinical inflammation in PA cases. These children should be followed closely in terms of metabolic disorders.