Urine 8-Hydroxy-2 '-Deoxyguanosine (8-OHdG) Levels of Dogs in Pyoderma

ERCAN N., FİDANCI U. R.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.59, sa.3, ss.163-168, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1501/vetfak_0000002520
  • Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.163-168
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

In this study, it is aimed to investigate correlation between antioxidative metabolism and the significant skin disease pyoderma in dogs and to demonstrate the extent of oxidative damage with 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels. Healthy (n=13), females diagnosed as pyoderma (untreated) (n=16), heathy (n=14) males and males diagnosed as pyoderma (untreated) (n=12) consisted the four study groups. In this aspect two control and two diseased groups were formed according to gender. Blood and urine samples were obtained from all the groups and bacterial swabs were collected from the diseased groups as well. Plasma malondialdehyde (MDA) besides urine 8-hydroxy-2'-deoxyguanosine levels measured with LC/MS/MS. MDA and 8-OHdG levels were increased in diseased groups. Differences among groups were found to be significant (p <= 0.05). In conclusion in our opinion untreated pyoderma cases could result in DNA damage.