Characterization of Nanoparticles Containing Achillea Phrygia and Their Antioxidant and Antiproliferative Properties
CUMHURIYET SCIENCE JOURNAL, cilt.43, sa.1, ss.27-32, 2022 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.17776/csj.1056496
- Dergi Adı: CUMHURIYET SCIENCE JOURNAL
- Derginin Tarandığı İndeksler: Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.27-32
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
In this study, antioxidant and antiproliferative properties of ‘‘Achillea phrygia’’ were investigated. Since the
antioxidant and antiproliferative activity of B sub-extract from plant’s chloroform extract is higher than other
extracts, B sub-extract of Achillea phrygia was used in the preparation of nanoparticles. Characterization of
nanoparticles was made, antiproliferative activities and IC50 values of nanoparticles and only chloroform extract
was calculated by cell culture studies and XTT cell viability test. According to the results, it was observed that
the extract-loaded chitosan nanoparticles had a strong antiproliferative activity in both MCF 7 and HT29 cells.
The results of this study support that bioactive extract of the Achillea phrygia plant can be prepared as an herbal
medicine candidate by preparing formulations with biopolymers and being investigated in cancer studies.