Increased cell proliferation and R.Msp1 fragmentation induced by 5-aza-2 '-deoxycytidine in rat testes related to the gene imprinting mechanism


Ozdemir O., Bulut H., Korkmaz M., Onarlioglu B., Colak A.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.52, ss.317-322, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 52 Konu: 4
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0940-2993(00)80056-1
  • Dergi Adı: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Sayfa Sayıları: ss.317-322

Özet

DNA methylation is one of the crucial mechanisms for cellular and tissue differentiation during developmental stages in mammals. 5-aza-2'-deoxycytidine, a specific cytosine DNA Methyltransferase inhibitor, is known to cause DNA hypomethylation in CpG, CpNpG and CCGG sequences. Therefore the present study was designed to determine the effects of 5-aza-2'-deoxycytidine on the germinal cells of the adult ra I: testicular tissue.