EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.52, sa.4, ss.317-322, 2000 (SCI-Expanded)
DNA methylation is one of the crucial mechanisms for cellular and tissue differentiation during developmental stages in mammals. 5-aza-2'-deoxycytidine, a specific cytosine DNA Methyltransferase inhibitor, is known to cause DNA hypomethylation in CpG, CpNpG and CCGG sequences. Therefore the present study was designed to determine the effects of 5-aza-2'-deoxycytidine on the germinal cells of the adult ra I: testicular tissue.