Synthesis and Biological Evaluation of Novel 1-(4-(Hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea Derivatives


Gezegen H. , Hepokur C. , Tutar U. , Ceylan M.

CHEMISTRY & BIODIVERSITY, cilt.14, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/cbdv.201700223
  • Dergi Adı: CHEMISTRY & BIODIVERSITY

Özet

A series of novel phenylurea containing 2-benzoylindan-1-one derivatives 3a - 3j were synthesized from the reaction of phenylurea-substituted acetophenones 1a - 1j with phthalaldehyde 2 under mild reaction conditions in good yields. All synthesized compounds were characterized by spectroscopic methods. The obtained compounds (3a - 3j) were evaluated for anticancer activity against HeLa and C6 cell lines. Antiproliferative activity was determined by the BrdU proliferation ELISA assay, 3f and 3g were found to be most active compounds. The compounds were also screened for antimicrobial activity and all compounds showed remarkable activity against used microorganisms.