Synthesis and Biological Evaluation of Novel 1-(4-(Hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea Derivatives

Gezegen H., Hepokur C., Tutar U., Ceylan M.

CHEMISTRY & BIODIVERSITY, cilt.14, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/cbdv.201700223
  • Dergi Adı: CHEMISTRY & BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: 2-Benzoylindan-1-one, Phenylurea, Anticancer activity, Apoptosis, Antimicrobial activity, ONE-POT SYNTHESIS, BETA-DIKETONE, 1,3-DICARBONYL COMPOUNDS, ANTIDEPRESSANT AGENTS, CHALCONE DERIVATIVES, 3-COMPONENT REACTION, BIGINELLI REACTION, UREA DERIVATIVES, DIARYL UREA, 1,3-DIKETONES
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A series of novel phenylurea containing 2-benzoylindan-1-one derivatives 3a - 3j were synthesized from the reaction of phenylurea-substituted acetophenones 1a - 1j with phthalaldehyde 2 under mild reaction conditions in good yields. All synthesized compounds were characterized by spectroscopic methods. The obtained compounds (3a - 3j) were evaluated for anticancer activity against HeLa and C6 cell lines. Antiproliferative activity was determined by the BrdU proliferation ELISA assay, 3f and 3g were found to be most active compounds. The compounds were also screened for antimicrobial activity and all compounds showed remarkable activity against used microorganisms.