Chromeno pyrimidine (CPs) derivatives were synthesized using green approach that involves reaction of multicomponent in one pot using water as solvent. The CPs molecules were tested as potential corrosion inhibitor for N80 steel in 15% hydrochloric acid solution using standard techniques such as weight loss (WT), electro- chemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP). CPs are effective corrosion inhibitors giving inhibition efficiency of 96.4% at only 200 mg/L concentration (CP-1). Adsorption of CPs with metal surface involve both physical and chemical interactions. EIS results depicted an increase in charge transfer resistance with increase in concentration of CPs. PDP study suggests mixed mode of CPs inhibition action. The adsorbed inhibitor film was confirmed by AFM and XPS spectra.