Design and in vitro, in vivo evaluation of antioxidant bioadhesive gelsfor burn treatment

Gokce G., Karavana S. Y., BAĞRIYANIK H. A., PEKÇETİN Ç., ALĞIN YAPAR E., Aybar Tural G., ...Daha Fazla

TURKISH JOURNAL OF BIOLOGY, cilt.46, sa.3, ss.251-262, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55730/1300-0152.2612
  • Dergi Adı: TURKISH JOURNAL OF BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.251-262
  • Anahtar Kelimeler: Taurine, antioxidant, bio-adhesive gel, burn wound model, MUCOADHESIVE, TAURINE, MELATONIN, CHITOSAN
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by oxidative stress.