Development of a new magnetic solid-phase extraction method prior to HPLC determination of naproxen in pharmaceutical products and water samples

Karataş A., OYMAK T., Çeli̇k A.

Journal of Pharmaceutical and Biomedical Analysis, cilt.249, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 249
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.jpba.2024.116336
  • Dergi Adı: Journal of Pharmaceutical and Biomedical Analysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, International Pharmaceutical Abstracts, Veterinary Science Database
  • Anahtar Kelimeler: HPLC, Magnetic biochar, Magnetic solid-phase extraction, Naproxen, Pharmaceutical contamination, Pumpkin peel
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In this study, a new magnetic solid phase extraction based on magnetic composite modified with biochar obtained from pumpkin peel was developed for the enrichment and extraction of Naproxen in lake water, tablet and urine samples. The effects of main parameters such as pH, extraction time, amount of adsorbent and sample volume, which affect magnetic solid phase extraction, were investigated. Under optimal conditions, intraday and interday precision values for naproxen were below 5.9, with accuracy (relative error) better than 7.0 %. The detection limit and preliminary concentration factor were 12 ng/mL and 10, respectively. The method proposed here can be used for routine analysis of naproxen in lake water, urine and tablets.