Akademik Veri Yönetim Sistemi
International Journal of Human and Health Sciences, cilt.4, sa.4, ss.251-256, 2020 (Hakemli Dergi)
Microbiota might be considered as an environmental factor which we are always exposed to
at high doses lifelong. It also includes bacteria and other organisms (fungus, protozoa, virus
and etc.) existing and living in our gastrointestinal tract and other anatomic regions (mouth,
skin, vagina). After it has been indicated that microbiota is related with human health and
many diseases such as cancer, studies in this field have gained speed and in view of the fact
that microbiota should be assessed as a new organ in our body has emerged. Microbiota
protects tissues from antigens and pathogens by strengthening mucosal barrier. Cancer
and inflammatory disorders increase when the barrier is destroyed. When the barrier is
destroyed, microbes might affect immune reactions in growing tumor microenvironments
more by forming proinflammatory or immunosuppressant programs. Microbiota which
accompanies intestinal and epithelial surface of human body affects starting and growing
of the cancer and impact of cancer treatment on tumor cells by intervening systemic
metabolism, immune system and inflammations. Many factors including environmental
conditions such as host genetics and diet regulate microbiota diversity and ultimately
regulate carcinogenesis and cancer treatment. In this review, we planned to emphasize
importance of the relation between microbiota and cancer which has been an important
subject of scientific researches in recent years.