Relationship Between Cancer and Microbiota


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Çetindağ Çiltaş A. , Taşkın Yılmaz F.

International Journal of Human and Health Sciences (IJHHS), cilt.4, ss.251-256, 2020 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 4 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.31344/ijhhs.v4i4.209
  • Dergi Adı: International Journal of Human and Health Sciences (IJHHS)
  • Sayfa Sayıları: ss.251-256

Özet

Microbiota might be considered as an environmental factor which we are always exposed to

at high doses lifelong. It also includes bacteria and other organisms (fungus, protozoa, virus

and etc.) existing and living in our gastrointestinal tract and other anatomic regions (mouth,

skin, vagina). After it has been indicated that microbiota is related with human health and

many diseases such as cancer, studies in this field have gained speed and in view of the fact

that microbiota should be assessed as a new organ in our body has emerged. Microbiota

protects tissues from antigens and pathogens by strengthening mucosal barrier. Cancer

and inflammatory disorders increase when the barrier is destroyed. When the barrier is

destroyed, microbes might affect immune reactions in growing tumor microenvironments

more by forming proinflammatory or immunosuppressant programs. Microbiota which

accompanies intestinal and epithelial surface of human body affects starting and growing

of the cancer and impact of cancer treatment on tumor cells by intervening systemic

metabolism, immune system and inflammations. Many factors including environmental

conditions such as host genetics and diet regulate microbiota diversity and ultimately

regulate carcinogenesis and cancer treatment. In this review, we planned to emphasize

importance of the relation between microbiota and cancer which has been an important

subject of scientific researches in recent years.