Akademik Veri Yönetim Sistemi
Indian Chemical Engineer, 2025 (ESCI)
Silica is a material with important properties that can be used in many various industrial areas. Silica nanoparticles (Si NPs), which can be produced in different sizes and shapes, are widely recognised as biomaterials and are commonly used in many medical and biomedical applications, such as drug delivery and bone tissue engineering. However, the effects of these particles on human health are an important issue that needs to be investigated. In this study, silica nanoparticles were synthesised at different pH levels (4, 7 and 10) by exposure to HCl using commercial sodium silicate. Obtained NPs were characterised using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy and X-ray Diffraction (XRD). Their morphological structure was examined by Scanning Electron Microscopy (SEM). While their chemical bond structure was examined by FTIR spectroscopy, their amorphous structure was determined by XRD analysis. Si NPs were obtained amorphous, spherical form and the size range of 50–200 nm depending on pH. Cytotoxic analyses were performed in vitro using the L929 cell line. The results indicated that the Si NPs did not exhibit any cytotoxic effects on L929 mouse fibroblasts.